abstract：:A broad range of cytokines are secreted during the inflammatory response by the immune system. Some cytokines promote inflammation, while others inhibit inflammation. Inflammatory cytokines work in harmony when they encounter external pathogens or internal dangers. Inflammation is resolved after the cause is eliminate...

journal_title：Experimental and molecular pathology

authors： Ye H,Wang Y,Yan J,Jenson AB

更新日期：2016-12-01 00:00:00

abstract：:Angiogenesis is a common feature of pathological processes including wound healing, tumor formation, and chronic inflammation. Chronic inflammation can also be associated with dilation or proliferation of lymph vessels. We examined blood vessels and lymphatics and the expression of pro- and anti-angiogenic genes in th...

journal_title：Experimental and molecular pathology

authors： HogenEsch H,Sola M,Stearns TM,Silva KA,Kennedy VE,Sundberg JP

更新日期：2016-12-01 00:00:00

abstract：:The relative resistance of fibroblasts to hypoxia and their remarkable adaptive plasticity in response to rapid changes in local tissue microenvironment made interstitial cardiac fibroblasts to be a key player in post-myocardial infarction myocardial repair. Cardiac fibroblasts are abundantly presented in the intersti...

journal_title：Experimental and molecular pathology

authors： Chistiakov DA,Orekhov AN,Bobryshev YV

更新日期：2016-10-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung...

journal_title：Experimental and molecular pathology

authors： Chen X,Shi C,Meng X,Zhang K,Li X,Wang C,Xiang Z,Hu K,Han X

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to evaluate if polymorphisms of APLN and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients. A case-control study was carried out including normotensive and hypertensive individuals. For these, two polymorphisms of APLN (rs3761581 and...

journal_title：Experimental and molecular pathology

authors： Esteban-Martínez RL,Pérez-Razo JC,Vargas-Alarcón G,Martínez-Rodríguez N,Cano-Martínez LJ,López-Hernández LB,Rojano-Mejía D,Canto P,Coral-Vazquez RM

更新日期：2016-08-01 00:00:00

abstract：:Overexpression of c-Yes has been noted to correlation with several human cancers. However, the effects of c-Yes on epithelial ovarian cancer (EOC) development remain unclear. The aim of this study is going to prove the effects of c-Yes and related mechanisms in proliferation, metastasis and invasion of EOC. Immunohist...

journal_title：Experimental and molecular pathology

authors： Jin Y,Huang M,Wang Y,Yi C,Deng Y,Chen Y,Jiang L,Wang J,Shen Q,Liu R,QinghuaXi

更新日期：2016-08-01 00:00:00

abstract：:There is a possibility that the aggresomes that form in the brain in neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these proteins cou...

journal_title：Experimental and molecular pathology

authors： French SW,Mendoza AS,Peng Y

更新日期：2016-06-01 00:00:00

abstract：:Attempts to establish a tissue bank from autopsy samples have led to uncovering of the secrets of many diseases. Here, we examined the length of time that the RNA from postmortem tissues is available for microarray analysis and reported the gene expression profile for up- and down-regulated genes during the postmortem...

journal_title：Experimental and molecular pathology

authors： Sobue S,Sakata K,Sekijima Y,Qiao S,Murate T,Ichihara M

更新日期：2016-06-01 00:00:00

abstract：:Myocardial ischemia-reperfusion (I/R) injury severely impacts the postoperative survival rate of coronary atherosclerotic heart disease. Radioprotective 105 kDa protein (RP105) is a regulator of Toll-like receptor 4 (TLR4), an inflammatory factor whose functions have been reported in myocardial I/R injury. To investig...

journal_title：Experimental and molecular pathology

authors： Li X,Yang J,Yang J,Dong W,Li S,Wu H,Li L

更新日期：2016-04-01 00:00:00

abstract：:Primary hepatic peripheral T-cell lymphoma (PTCL) is exceedingly rare. We encountered such a case in a 58-year-old Hispanic female with a history of chronic sinusitis and hypothyroidism who presented with 4weeks of fever and weight loss. Laboratory studies showed altered liver function and mild pancytopenia. Hepatitis...

journal_title：Experimental and molecular pathology

authors： Peng Y,Cai J,Yue C,Qing X

更新日期：2016-02-01 00:00:00

abstract：INTRODUCTION:Angiogenesis is the growth of both new vascular and lymphatic blood vessels from the existing vasculature. During this process, blood endothelial cells (BECs) and lymphatic endothelial cells (LECs) express specific markers, which help their discrimination and easier identification. Since the coronary throm...

journal_title：Experimental and molecular pathology

authors： Rakocevic J,Kojic S,Orlic D,Stankovic G,Ostojic M,Petrovic O,Zaletel I,Puskas N,Todorovic V,Labudovic-Borovic M

更新日期：2016-02-01 00:00:00

abstract：:Currently there is critical need for the identification of reliable biomarkers to help guide clinical management of multiple sclerosis (MS) patients. We investigated the combined roles of Response Gene to Complement 32 (RGC-32), FasL, CDC2, AKT, and IL-21 as possible biomarkers of relapse and response to glatiramer ac...

journal_title：Experimental and molecular pathology

authors： Kruszewski AM,Rao G,Tatomir A,Hewes D,Tegla CA,Cudrici CD,Nguyen V,Royal W 3rd,Bever CT Jr,Rus V,Rus H

更新日期：2015-12-01 00:00:00

abstract：:Huntingtin-interacting protein 1-related (HIP1R) is an endocytic protein involved in receptor trafficking, including regulating cell surface expression of receptor tyrosine kinases. We have previously shown that low HIP1R protein expression was associated with poorer survival in diffuse large B-cell lymphoma (DLBCL) p...

journal_title：Experimental and molecular pathology

authors： Wong KK,Ch'ng ES,Loo SK,Husin A,Muruzabal MA,Møller MB,Pedersen LM,Pomposo MP,Gaafar A,Banham AH,Green TM,Lawrie CH

更新日期：2015-12-01 00:00:00

abstract：:In the present study, chemopreventive efficacy of hesperidin was evaluated against ferric nitrilotriacetate (Fe-NTA) induced renal oxidative stress and carcinogenesis in wistar rats. Nephrotoxicity was induced by single intraperitoneal injection of Fe-NTA (9 mg Fe/kg b.wt). Renal cancer was initiated by the administra...

journal_title：Experimental and molecular pathology

authors： Siddiqi A,Hasan SK,Nafees S,Rashid S,Saidullah B,Sultana S

更新日期：2015-12-01 00:00:00

abstract：:Protection of intestinal graft mucosa during cold preservation is still an unmet need in clinical practice, thus affecting the success of transplantation. The present study investigates the ability of two ischemic preconditioning (IPC) procedures to limit cold preservation injury. Three groups of Sprague-Dawley rats w...

journal_title：Experimental and molecular pathology

authors： Jonecova Z,Toth S,Maretta M,Ciccocioppo R,Varga J,Rodrigo L,Kruzliak P

更新日期：2015-10-01 00:00:00

abstract：:Macrophages are crucially involved in the pathophysiology of acute pancreatitis. Soluble CD163 (sCD163) is specifically released from macrophages and systemic levels are increased in inflammatory diseases. Here, sCD163 was measured in serum of 50 patients with acute pancreatitis to find out possible associations with ...

journal_title：Experimental and molecular pathology

authors： Karrasch T,Brünnler T,Hamer OW,Schmid K,Voelk M,Herfarth H,Buechler C

更新日期：2015-10-01 00:00:00

abstract：:This study aimed to identify the expression of semaphorin 3C (SEMA3C) in the normal-metastatic spectrum of breast and oral cancers, and correlate expression with microvessel density (MVD, CD31), a surrogate marker of angiogenesis. Histological analysis revealed that SEMA3C expression was reduced in the development of ...

journal_title：Experimental and molecular pathology

authors： Cole-Healy Z,Vergani P,Hunter K,Brown NJ,Reed MW,Staton CA

更新日期：2015-08-01 00:00:00

abstract：:Breast cancer (BC) is a major health problem for women around the world. Although advances in the field of molecular therapy have been achieved, the successful therapeutic management of BC, particularly metastatic disease, remains a challenge for patients and clinicians. One of the areas of current investigation is th...

journal_title：Experimental and molecular pathology

authors： Ejaeidi AA,Craft BS,Puneky LV,Lewis RE,Cruse JM

更新日期：2015-08-01 00:00:00

abstract：:Soft tissue sarcomas (STSs) are comparatively rare malignant tumors with poor prognosis. STSs predominantly arise from mesenchymal differentiation. MicroRNA-34b/c, the transcriptional targets of tumor suppressor p53, possesses tumor suppressing property. Hypermethylation of miR-34b/c has been associated with tumorigen...

journal_title：Experimental and molecular pathology

authors： Xie Y,Zong P,Wang W,Liu D,Li B,Wang Y,Hu J,Ren Y,Qi Y,Cui X,Chen Y,Liu C,Li F

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Ethanol has been considered as a lifestyle risk factor for cancer in humans. While some studies have indicated that alcohol intake has a preventive effect for renal cell cancer, others have not. The metabolism of alcohol in cancer cells may be in many ways different than in healthy tissue and its disturbance...

journal_title：Experimental and molecular pathology

authors： Orywal K,Jelski W,Werel T,Szmitkowski M

更新日期：2015-06-01 00:00:00

abstract：:Increased levels of prolactin (PRL) have recently been associated with carcinogenesis and the exacerbation of autoimmune diseases, and might be involved in the progression of tuberculosis (TB). To investigate the relationship between PRL and prolactin receptor (PRLr) expression with inflammatory response and apoptosis...

journal_title：Experimental and molecular pathology

authors： López-Rincón G,Mancilla R,Pereira-Suárez AL,Martínez-Neri PA,Ochoa-Zarzosa A,Muñoz-Valle JF,Estrada-Chávez C

更新日期：2015-06-01 00:00:00

abstract：:We have previously shown that RGC-32 is involved in cell cycle regulation in vitro. To define the in vivo role of RGC-32, we generated RGC-32 knockout mice. These mice developed normally and did not spontaneously develop overt tumors. To assess the effect of RGC-32 deficiency on cell cycle activation in T cells, we de...

journal_title：Experimental and molecular pathology

authors： Tegla CA,Cudrici CD,Nguyen V,Danoff J,Kruszewski AM,Boodhoo D,Mekala AP,Vlaicu SI,Chen C,Rus V,Badea TC,Rus H

更新日期：2015-06-01 00:00:00

abstract：:We have previously reported the mechanism behind the myocardial injury and the activation of autonomic nervous system during the ischemia-reperfusion (IR) of the rat brain. This study was planned to investigate the effect of carvedilol, a β-blocker, in improving the myocardial injury caused by IR of the rat brain. We ...

journal_title：Experimental and molecular pathology

authors： Harima M,Arumugam S,Wen J,Pitchaimani V,Karuppagounder V,Afrin MR,Sreedhar R,Miyashita S,Nomoto M,Ueno K,Nakamura M,Watanabe K

更新日期：2015-06-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Experimental and molecular pathology

authors： Wu N,Zhang X,Jia P,Jia D

更新日期：2015-05-07 00:00:00

abstract：BACKGROUND:DNA methylation is the most important epigenetic change involved in the control of gene expression in human cells. Methylation of the p16(INK4a) gene occurs early in the development of cervical cancer. Low-grade squamous intraepithelial lesions (LSILs) are prevalent, and their behavior is variable. OBJECTIV...

journal_title：Experimental and molecular pathology

authors： Silveira FA,Almeida G,Furtado Y,Silva KS,Maldonado P,Cavalcanti S,Carvalho Mda G

更新日期：2015-04-01 00:00:00

abstract：:Studies of spontaneous mutations in mice have provided valuable disease models and important insights into the mechanisms of human disease. Ruffled (rul) is a new autosomal recessive mutation causing abnormal hair coat in mice. The rul allele arose spontaneously in the RB156Bnr/EiJ inbred mouse strain. In addition to ...

journal_title：Experimental and molecular pathology

authors： Herbert Pratt C,Potter CS,Fairfield H,Reinholdt LG,Bergstrom DE,Harris BS,Greenstein I,Dadras SS,Liang BT,Schofield PN,Sundberg JP

更新日期：2015-04-01 00:00:00

abstract：:The reparative reaction is considered to be important during the occurrence of collapse in the femoral head with osteonecrosis (ONFH), but little is known about the long-term reparative process. The aim of this study was to determine and analyze the altered microRNA expression profile in the reparative interface of ON...

journal_title：Experimental and molecular pathology

authors： Yuan HF,Von Roemeling C,Gao HD,Zhang J,Guo CA,Yan ZQ

更新日期：2015-04-01 00:00:00

abstract：:Formin-like 3 (FMNL3), a member of diaphanous-related formins subfamily, plays an important role in cytoskeleton reorganization, cell adhesion and cancer cell invasion in vitro. This study aimed to explore the expression of FMNL3 in colorectal carcinoma (CRC) cell-lines and tissues, and further evaluate its prognostic...

journal_title：Experimental and molecular pathology

authors： Zeng YF,Xiao YS,Lu MZ,Luo XJ,Hu GZ,Deng KY,Wu XM,Xin HB

更新日期：2015-04-01 00:00:00

abstract：:Pentraxins belong to the superfamily of conserved proteins that are characterized by a cyclic multimeric structure. Pentraxin 3 (PTX3) is a long pentraxin which can be produced by different cell types upon exposure to various inflammatory signals. Inside the neutrophil PTX3 is stored in form of granules localized in t...

journal_title：Experimental and molecular pathology

authors： Razvina O,Jiang S,Matsubara K,Ohashi R,Hasegawa G,Aoyama T,Daigo K,Kodama T,Hamakubo T,Naito M

更新日期：2015-02-01 00:00:00

abstract：:Ameloblastoma is a benign odontogenic neoplasm that may exhibit aggressive biological behavior as evidenced by its rapid growth and significance recurrence rates following initial surgical resection. Currently, the only therapy for ameloblastoma is surgical, and adjunctive treatment modalities are needed to mitigate t...

journal_title：Experimental and molecular pathology

authors： Jhamb T,Kramer JM

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:The aim of the present work was to investigate the mechanism of transforming growth factor (TGF)-β1 and Sloan-Kettering Institute (Ski) in the pathogenesis of hypertrophic scars (HS). BACKGROUND:Wound healing is an inherent process, but the aberrant wound healing of skin injury may lead to HS. There has been...

journal_title：Experimental and molecular pathology

authors： Chen Z,Li W,Ning Y,Liu T,Shao J,Wang Y

更新日期：2014-12-01 00:00:00

abstract：:Periostin is a modular glycoprotein frequently observed to be a major constituent of the extracellular milieu of mass-forming intrahepatic cholangiocarcinoma and other desmoplastic malignant tumors. In intrahepatic cholangiocarcinoma, as well as in desmoplastic pancreatic ductal adenocarcinoma, periostin is overexpres...

journal_title：Experimental and molecular pathology

authors： Sirica AE,Almenara JA,Li C

更新日期：2014-12-01 00:00:00

abstract：:This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic ste...

journal_title：Experimental and molecular pathology

authors： Neuman MG,French SW,French BA,Seitz HK,Cohen LB,Mueller S,Osna NA,Kharbanda KK,Seth D,Bautista A,Thompson KJ,McKillop IH,Kirpich IA,McClain CJ,Bataller R,Nanau RM,Voiculescu M,Opris M,Shen H,Tillman B,Li J,Liu H

更新日期：2014-12-01 00:00:00

abstract：:Immunological dysfunction is a primary characteristic of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been shown to ameliorate the clinical signs of EAE by suppressing the productio...

journal_title：Experimental and molecular pathology

authors： Liu N,Kan QC,Zhang XJ,Xv YM,Zhang S,Zhang GX,Zhu L

更新日期：2014-12-01 00:00:00

abstract：:The most common type of liver cancer, hepatocellular carcinoma (HCC), affects over 500,000 people in the world. In the present study, liver tumor resections were used to prepare tissue arrays to examine the intensity of fluorescence of IHC stained stem cell markers in liver tissue from malignant HCC tumors and accompa...

journal_title：Experimental and molecular pathology

authors： Buzzanco A,Gomez A,Rodriguez E,French BA,Tillman BA,Chang S,Ganapathy E,Junrungsee S,Zarrinpar A,Agopian VG,Naini BV,French SW Jr,French SW Sr

更新日期：2014-12-01 00:00:00

abstract：:A continuing conundrum of cancer biology is the dichotomous function of transcription factors that regulate both proliferation and apoptosis, seemingly opposite results. Previous results have indicated that regulated entry into the S-phase of the cell cycle can be anti-apoptotic. Indeed, tumor suppressor genes can be ...

journal_title：Experimental and molecular pathology

authors： Szekeres K,Koul R,Mauro J,Lloyd M,Johnson J,Blanck G

更新日期：2014-12-01 00:00:00

abstract：:Fine-needle aspiration biopsy remains the mainstay for preoperative examination of thyroid nodules; however, it does not provide a definite diagnosis in up to 25% of nodules. Considerable studies have been performed to identify molecular markers to resolve this diagnostic dilemma. The aim of this study was to establis...

journal_title：Experimental and molecular pathology

authors： Liu S,Gao A,Zhang B,Zhang Z,Zhao Y,Chen P,Ji M,Hou P,Shi B

更新日期：2014-10-01 00:00:00

abstract：:Recent research has shown that oncogenic human papillomavirus (HPV) DNA, which is currently used in the screening and diagnosis of cervical cancer, can be detected not only in high-grade cervical lesions, but also in low-grade cervical lesions and normal tissues. For this reason, HPV tests targeting the E6 and E7 mRNA...

journal_title：Experimental and molecular pathology

authors： Munkhdelger J,Kim G,Wang HY,Lee D,Kim S,Choi Y,Choi E,Park S,Jin H,Park KH,Lee H

更新日期：2014-10-01 00:00:00

abstract：:Myelofibrosis is characterized by reticulin and/or collagen fibrosis in the bone marrow stroma resulting in secondary cytopenia. In addition to clonal hematologic neoplasms, myelofibrosis may also develop in association with other clinical conditions, including hematological disorders, solid malignancies, Down syndrom...

journal_title：Experimental and molecular pathology

authors： Qing X,Sun N,Yeh J,Yue C,Cai J

更新日期：2014-10-01 00:00:00

abstract：:Mucoepidermoid carcinoma (MEC) is the most prevalent malignant tumor in major and minor salivary glands (SGs). We have recently identified human cytomegalovirus (hCMV) as a principle component in the multifactorial causation of SG-MEC. This finding is corroborated by the ability of the purified mouse CMV (mCMV) to ind...

journal_title：Experimental and molecular pathology

authors： Melnick M,Deluca KA,Jaskoll T

更新日期：2014-08-01 00:00:00